1996
Sinclair says one of his 1996 papers raised red wine sales by about 30%.
“One of my papers in 1996 caused red wine sales to go up 30% and stayed up.”
Topic
David Sinclair
33 facts from 3 episodes, in date order. These are what speakers said on the shows, each linked to the moment it was said. They aren't independently verified.
2005
Sinclair says that a 2005 Science paper showed low insulin and insulin-like growth factor levels turn on longevity genes.
“we showed in 2005 uh in a science paper that if you have low levels of insulin and another molecule called insulin-like growth factor those low levels turn on the longevity genes.”
2022
Sinclair said the eye age-reversal therapy would be tested in monkeys first, with a first human patient expected in 2022 or early 2023 to try to restore vision.
“we're going to be testing the treatment on, um, monkeys, uh, for just for safety reasons, uh, and then the first patient should be done sometime in 2022, early 2023, and we're gonna try to recover blindness.”
2026
Sinclair's planned eye therapy introduces three genes into the optic nerve and activates them for six to eight weeks.
“we're introducing a set of three genes into this optic nerve at the back of the eye and turning them on for six to eight weeks.”
Undated
David Sinclair argues that aging is fundamentally a loss of information, comparable to degradation from repeated photocopying.
“the fact that I think aging is a loss of information in the same way that when you Xerox something a thousand times, you'll lose that information.”
Undated
Sinclair describes the epigenome as the system that decides which genes are played in each type of cell, using a compact disc analogy.
“the epigenome is the reader that says, okay, in this cell, we need to play that set of songs, and in this other cell, we have to play a different set of songs.”
Undated
Sinclair says the DNA in a single human cell is about six feet long and must be wrapped carefully to fit inside it.
“DNA is six foot long. So if you join your chromosomes together, you get a six foot per cell.”
Undated
Sinclair says his lab accelerated aging in mice by damaging DNA, producing animals about 50 percent older with a bent spine and gray hair.
“We can actually do this to a mouse. We can accelerate that process, and we get an old mouse, 50% older, and it has this bent spine, kyphosis, it has gray hair, its organs are old.”
Undated
Sinclair says a lab colleague, Michael Bunkowski, produced a mouse that lived five years, versus a typical lifespan of about two years, by combining fasting with a low growth hormone mutation.
“A guy in my lab, Michael Bunkowski, he had the longest lived mouse. A mouse typically lives about two and a bit years. He had a mouse that lived five years”
Undated
Sinclair says supplemental data from his resveratrol mouse study showed mice given resveratrol every other day on a normal diet lived dramatically longer than other groups.
“The mice that were given resveratrol every second day on a normal diet live dramatically longer than any other group.”
Undated
Sinclair says he takes 1,000 milligrams of resveratrol daily, an amount he says cannot be obtained from red wine, and he said he would need about 200 glasses a day.
“So realistically, you can only get the one thousand milligrams that I take a day from a supplement that's pure.”
Undated
Sinclair says that taking resveratrol with food raised his blood levels fivefold.
“And when we included it with food, the levels in my blood went up fivefold.”
Undated
Sinclair says unpublished clinical trial data show NMN taken for about two weeks doubles blood NAD levels on average.
“But if you take it for about two weeks, you'll double, on average, double your NAD levels in the blood.”
Undated
Sinclair says a Cell paper from his lab showed NMN let old mice run 50 percent further, while nicotinamide riboside at the same dose had no effect.
“NMN, we've shown in a cell paper a few years ago, makes mice run further. Old mice can run 50% further because they have better blood flow, better energy.”
Undated
Sinclair says old female mice, infertile since about twelve months, regained fertility about six weeks after receiving NMN.
“Gave them NMN, and I think it was only six weeks later, they had offspring, they became fertile again”
Undated
Sinclair says he has taken a statin since age 29 because of a family history of heart disease and cholesterol above 300.
“I've been taking a statin since I was twenty nine, and that's cause I forced my same doctor to give me the statin.”
Undated
Sinclair says Peter Attia pointed him to a study that he believes shows dietary cholesterol has almost no effect on blood cholesterol.
“our friend Peter Attia, uh, brought to my attention recently a new study that I think definitively said that dietary cholesterol has almost zero impact on blood cholesterol levels.”
Undated
Sinclair says that altering resveratrol so it was no longer an antioxidant still extended yeast lifespan, suggesting antioxidant activity was not the mechanism.
“If we changed one atom to make it not an antioxidant, guess what? It still worked fine.”
Undated
Sinclair says the eye therapy delivers genes into the retina that are switched on with the antibiotic doxycycline for four to eight weeks in mice, restoring vision.
“The genes go into the retina and we can turn it on with a drug called doxycycline, and we do that in the mice for four to eight weeks.”
Undated
Sinclair says he and Ray Kurzweil published the metabolic winter hypothesis, proposing that humans were historically often hungry or cold and now rarely are.
“We published what's called the metabolic winter hypothesis, which is few tens of thousands of years ago, we were either hungry or cold or both”
Undated
David Sinclair says his lab's age-reversal technology has cured blindness in animals including primates.
“What we're finding in animals, that includes primates, is that we can cure things that have previously been impossible, including blindness, by the way.”
Undated
An independent lab used Sinclair's three-gene technology in very old mice by injecting it into the vein.
“They injected into the vein of the mouse the old mice, uh, and turned it on in these really old mice.”
Undated
Sinclair's information theory of aging holds that loss of epigenetic control information, not DNA itself, drives aging.
“the information theory of aging states that the information that's in a cell, which includes the D N A, but actually more importantly for aging, is the control systems, the epigenome.”
Undated
Sinclair's lab created 'ice mice', named for inducible changes to the epigenome, to test whether DNA breaks cause aging.
“We call them the ice mice. Ice stands for inducible changes to the epigenome, and we were able to induce these changes.”
Undated
The ice mice carried a slime mold gene, activated by tamoxifen, that cuts DNA without causing cancer or mutations.
“turned on a gene from a slime mold, something you might find in the forest, that breaks D N A of the mouse, but does it in a way that doesn't cause cancer or mutations”
Undated
Sinclair says the treated mice aged much faster than untreated twins, with gray fur and age-related diseases about ten months later.
“they were super gray and super old and had all the diseases of aging 50 faster than their twins that we didn't treat.”
Undated
Sinclair says deep protein cleanup through chaperone-mediated autophagy happens after about two and a half to three days of fasting.
“the true, real deep clean cleansing of old proteins and damage damaged proteins happens after two and a half to three days. And it's called chaperone-mediated autophagy.”
Undated
Sinclair says he has taken a statin to lower LDL cholesterol since age 30.
“So I've actually been on a statin to lower my L D L since I was thirty.”
Undated
Sinclair takes daily baby aspirin despite medical groups no longer recommending it for the average person, citing his high cardiovascular risk.
“I take a baby aspirin every day, even though some doctors um, and some institutions of doctors say, don't take it anymore”
Undated
Sinclair's gene therapy uses an AAV2 delivery vector designed to target retinal nerves and is said to be ready for human use pending FDA approval.
“It's called an A A V two. Um, long story short, these are ready to go into humans.”
Undated
Sinclair says AI was used to screen about 8 billion candidate molecules in search of a pill that reproduces the effect of the three genes.
“We screened about 8 billion candidates using A I, and right now we're doing the bench lab work to see if one of them or more works.”
Undated
Sinclair says he thinks there is a better than 50% chance that reality is a simulation.
“I think there's a better than 50% chance that this is simulated.”
Undated
Andrew Huberman said David Sinclair told Joe Rogan's podcast that blindness caused by GLP-1 drugs had doubled, a claim Huberman considered alarming and overstated.
“David Sinclair recently went on Rogan and said, you know, the amount of of blindness caused by GLPs has doubled, which scared everybody.”
Episodes