1971
Dave Ricks said the incretin effect, in which gut hormones trigger insulin release after eating, was discovered in 1971.
“This was discovered in 1971, basically, called the Incretin Effect.”
Topic
GLP-1
6 facts from 3 episodes, in date order. These are what speakers said on the shows, each linked to the moment it was said. They aren't independently verified.
2006
Dave Ricks said Eli Lilly launched the first GLP-1 medicine, a twice-daily injection, in 2006.
“We launched the first GOP-1 twice a day injection in 2006.”
Undated
Huberman says GLP-1 was discovered through studies of Gila monsters, reptiles that can go long periods without eating.
“it was actually discovered in Gila monsters. These are these um reptiles that can go long periods of time without eating”
Undated
Huberman says GLP-1 stimulates thermogenesis, the active use of metabolic energy, in addition to promoting fullness.
“it turns out it also stimulates thermogenesis. Now, thermogenesis is the active utilization of more metabolic energy”
Undated
Huberman says elevated GLP-1 helps convert white fat cells into beige and brown fat cells.
“it communicates to those white fat cells and helps convert them into beige and brown fat cells.”
Undated
Andrew Huberman said Gila monsters make a peptide (transcribed as 'extendin', i.e. exendin) that turned out to be homologous to human glucagon-like peptide-1.
“It's because they make a peptide called extendin, which turned out to be homologous to glucagon-like peptide one in humans.”
Episodes