2015
Peter Attia says he has taken an injectable PCSK9 inhibitor every two weeks since about 2015.
“I probably started in 2015, so it's an injectable drug. I take it every two weeks and it's a called a PCSK9 inhibitor”
Topic
Peter Attia
61 facts from 4 episodes, in date order. These are what speakers said on the shows, each linked to the moment it was said. They aren't independently verified.
2016
In 2016 Peter Attia traveled to Easter Island, the birthplace of rapamycin, with David Sabatini, Navdeep Chandel and Tim Ferriss.
“in 2016, I went to Easter Island with David Sabatini and Nav Chandel and Tim Ferriss.”
2017–2020
Peter Attia says he spent two weeks at a facility in Kentucky in 2017 and three weeks at one in Arizona in 2020, both for emotional health treatment.
“In 2017, I spent two weeks at a facility in Kentucky. In 2020, I spent three weeks at a facility in Arizona.”
2026
Peter Attia says the Matt Kaeberlein dog aging study testing rapamycin is expected to report results in 2026.
“Matt Kabelin's dog aging study, um, which, uh, is is is gonna be an exciting readout in 2026.”
Undated
Sinclair says Peter Attia pointed him to a study that he believes shows dietary cholesterol has almost no effect on blood cholesterol.
“our friend Peter Attia, uh, brought to my attention recently a new study that I think definitively said that dietary cholesterol has almost zero impact on blood cholesterol levels.”
Undated
Peter Attia says atherosclerotic cardiovascular disease kills roughly 18 to 19 million people a year worldwide, compared with about 11 million for cancer.
“We're talking about eighteen to 19 million people a year that are dying of atherosclerotic cardiovascular disease in the world, whereas number two is cancer at about 11 million.”
Undated
Peter Attia says he uses two automated blood pressure cuffs, one from Withings and one from Omron.
“One's called Withings, and the other one's made by a company called Omron O M R O N.”
Undated
Peter Attia says the lungs' alveolar air sacs, if spread out, would easily cover a tennis court.
“If you took the alveolar air sacs of the lungs and spread them out, you would easily cover a tennis court.”
Undated
Peter Attia says air particles smaller than 2.5 microns (PM 2.5) get straight into the body.
“particulates that are less than 2.5 microns are are getting straight into the body”
Undated
Peter Attia says that embryos unable to synthesize cholesterol do not survive.
“So if you cannot synthesize cholesterol, you can't live you, you'll die in utero.”
Undated
Peter Attia says the body makes its own cholesterol and that cholesterol eaten in food is largely irrelevant.
“We make all of our own cholesterol, the cholesterol that you eat in food largely irrelevant.”
Undated
Peter Attia says LDL-C measures the cholesterol content of LDL particles while ApoB measures their number, and that ApoB predicts cardiovascular risk better.
“LDL C measures the total concentration of cholesterol in the LDLs, apo B measures the number of them, and they're different, but one of them is far superior at predicting risk, and it's apo B.”
Undated
Peter Attia says that nearly every man in his family has died prematurely of atherosclerosis.
“where basically every man in my family except one has died of atherosclerosis, and they have all done so very prematurely.”
Undated
Peter Attia says MACE, or major adverse cardiac event, is the measure medicine uses to estimate ten-year cardiovascular risk.
“MACE stands for major adverse cardiac event. It is the metric we use in medicine.”
Undated
Peter Attia says that for patients with no calcification or soft plaque, he is satisfied with an ApoB near 60 mg/dL, and he targets 30 to 40 mg/dL in higher-risk patients.
“we might be satisfied with a person's apo B being at the fifth percentile of the population, which would be about sixty milligrams per deciliter.”
Undated
Peter Attia considers triglycerides above 100 mg/dL elevated, although most laboratories treat up to 150 mg/dL as normal.
“and I consider anything over one hundred to be elevated, even though most laboratory tests would consider normal to be up to 150 milligrams per deciliter.”
Undated
Peter Attia describes a patient wearing a continuous glucose monitor whose glucose rose about ten points after starting rosuvastatin, and who recovered when the drug was stopped.
“he pings us like a couple weeks later, and he's like, Man, my glucose is like ten points up consistently from where it has normally been.”
Undated
Peter Attia recalls a medical school pathology professor saying the most common presentation of a heart attack is death.
“The single most common presentation for a myocardial infarction is death.”
Undated
Peter Attia says the kidney receives roughly twenty to twenty-five percent of the blood pumped with each heartbeat, making it sensitive to high blood pressure.
“This is a tiny organ that on every pump of your heart is getting twenty to twenty five of your blood.”
Undated
Peter Attia says the evidence, including a JAMA analysis with genetic studies, shows no dose of alcohol is healthy.
“It's actually pretty clear that there is no dose of ethanol that is healthy.”
Undated
Peter Attia says the lifetime chance of getting cancer is between one in three and one in four.
“put it this way, somewhere between one in three and one in four chance. Anyone listening to this or watching this is gonna get cancer in their lifetime.”
Undated
Peter Attia says over ninety-five percent of cancers arise from acquired somatic mutations, not inherited germline mutations.
“But ninety five plus percent of cancers are not arising from germline mutations, they are arising from somatic mutations or acquired mutations.”
Undated
Peter Attia says a waist circumference above half of one's height is a warning sign and a better indicator than body mass index.
“but if your waist circumference is more than fifty of your height, you should be concerned.”
Undated
Peter Attia says that about 80% of patients with stage three colon cancer treated with chemotherapy are alive at five years, compared with very low survival at stage four.
“80% of those people are alive in five years, so night and day difference in survival.”
Undated
Peter Attia says an off-the-shelf CT scanner delivers about twenty millisieverts of radiation for a coronary CT angiogram, while better scanners can do it for about two.
“Um, an off the shelf scanner for this is twenty millisieverts of radiation.”
Undated
Peter Attia says the Prenuvo whole-body MRI technology is based in Vancouver and was for a long time the only scanner of its kind in the world.
“Um, it's a super interesting technology based out of Vancouver, and for a long time, that was the only scanner in the world.”
Undated
Peter Attia says about 55% of people carry two copies of the APOE3 gene variant, and about 25% have the 3/4 combination.
“Three, three is now the most common, three is the most common, so double three is fifty five ish percent of the population.”
Undated
Peter Attia says fentanyl-related deaths now outnumber other accidental deaths among people under 65.
“so fentanyl related deaths have basically squashed all other deaths below 65 on the accidental front.”
Undated
Peter Attia says people aged 65 or older who break a femur or hip face roughly a 15 to 30 percent chance of dying within twelve months.
“Your twelve month mortality, the probability you will be dead in twelve months after that break, if you're 65 or older, depending on the study, is about 15 to 30.”
Undated
Peter Attia says the birth of his daughter when he was 35 was the first moment his focus shifted from performance toward longevity.
“But when my daughter was born, when I was 35, uh, that was the 1st time that everything kind of pivoted.”
Undated
Peter Attia says that until about 150 years ago human life expectancy was in the high 30s to low 40s, with most people dying of trauma and infection.
“up until about 150 years ago, life expectancy would have been high 30s, low 40s, and most of us succumbed to fast death.”
Undated
Peter Attia says the light microscope, which did not exist until about 140 years ago, let scientists see bacteria and helped launch modern medicine.
“light microscope, which, you know, up until 140 years ago or so didn't exist, allowed scientists and doctors to be able to actually see these microscopic things called bacteria”
Undated
Peter Attia says roughly one in ten people carry elevated Lp(a), a blood lipid that sharply raises cardiovascular disease risk.
“about a one in ten chance you might have a biomarker called Lp little a, for example, which is just a a certain lipid in your body.”
Undated
Peter Attia says studies of young people who died of unrelated causes, such as car accidents or war, show advanced disease in their coronary arteries.
“And we look at their the arteries of their heart, we already see quite advanced disease. So the truth of it is, you already have pretty significant disease in your coronary arteries.”
Undated
Peter Attia says muscle mass and spontaneous physical activity fall sharply around age 75 in both men and women.
“the cliff for both is seventy five for both men and women.”
Undated
Peter Attia says the all-cause mortality hazard ratio for smokers versus non-smokers is about 1.5.
“it's about 1.5, meaning a smoker is about 50 more likely to die in any given year than a non-smoker.”
Undated
Peter Attia says type 2 diabetes carries a hazard ratio of about 1.4 for all-cause mortality, roughly a 40% higher risk of death.
“when it comes to all cause mortality, every cause of death, it's about 1.4 hazard ratio 40 more, about a 40 increase in all cause mortality.”
Undated
Peter Attia says a VO2 max of about 56 ml of oxygen per kilogram per minute puts a 30-year-old man in the top 2.5% for his age and sex.
“fifty six would put you in the top two and a half percent.”
Undated
Peter Attia says the winner of the Tour de France has a VO2 max of about 85.
“the guy who wins the Tour de France this year is eighty five.”
Undated
Peter Attia says glucose is stored in the liver and muscles, with muscle holding about 80% of it.
“stored in the liver and in the muscles, but the muscles store 80% of it.”
Undated
Peter Attia says that after age 65, breaking a hip or femur in a fall brings a 15 to 30% chance of death within twelve months.
“if you fall, which is pretty likely, and you break your hip or your femur, the long bone in your leg, there's a fifteen to 30% chance you will be dead within the next twelve months.”
Undated
Peter Attia says going from no exercise to ninety minutes a week reduces all-cause mortality by about 15%.
“Going from zero activity to just ninety minutes a week is about 15% reduction in all-cause mortality.”
Undated
Peter Attia says he spent 21 days in a second inpatient trauma treatment facility after an earlier two-week stay.
“And then again, I had to do it for three weeks at a different facility. So again, 21 days of inpatient treatment.”
Undated
Peter Attia says that recording kind voice messages to himself multiple times a day ended his harsh inner critic within about four months.
“I'm audibly doing this multiple times a day, and within about four months, the voice just went away.”
Undated
Peter Attia says he rucks, which means walking with a weighted backpack, three or four times a week in hilly Austin, Texas.
“So I ruck three or four times every week, and luckily, where I live in Austin, Texas, it's incredibly hilly”
Undated
Peter Attia explains that table sugar, or sucrose, is one molecule of glucose bonded to one molecule of fructose.
“sucrose, which is the white powder you would put in your coffee or tea, that's just one molecule of glucose and one molecule of fructose stuck together.”
Undated
Peter Attia says human ancestors slept an average of about 7 to 8 hours per 24 hours, which he cites as evidence that sleep is essential.
“our ancestors slept on an average of about 7 to 8 hours every 24 hours”
Undated
Peter Attia says women have about ten times more testosterone than estrogen, though about one-twentieth the testosterone level of men.
“women have 10 times more testosterone in them than they do estrogen”
Undated
Peter Attia says the enzyme five alpha reductase converts testosterone into DHT, the hormone driving hair loss, and that finasteride and dutasteride block it.
“So testosterone gets turned into DHT by an enzyme called five alpha reductase.”
Undated
According to Peter Attia, mice engineered to overexpress the Klotho gene lived 15 to 20 percent longer.
“when they overexpressed that same gene that they had just knocked out and killed the mouse, the thing was living fifteen to 20% longer.”
Undated
Attia says the Klotho gene was found by accident when a Japanese researcher studying hypertension noticed a knockout mouse strain that died quickly from neurodegeneration.
“there was a a researcher in Japan who was really interested in understanding hypertension”
Undated
Peter Attia says he takes rapamycin for about two months and then stops for a month because it causes mouth ulcers.
“I'm probably on it for two months and then off it for a month.”
Undated
Peter Attia says caloric restriction and rapamycin are the only interventions that have extended life across yeast, worms, flies and mammals.
“It's very important to understand there are only two interventions full stop that have ever extended life across those four categories of eukaryotes. Caloric restriction and rapamycin.”
Undated
Attia says the dog aging study had a funding gap of about $2.5 million, which a group including his patients raised.
“there was a shortfall of about $2.5 million, um, to do the the study that Matt really wanted to do.”
Undated
Attia says a small fraction of NAD is consumed by sirtuin enzymes during DNA repair.
“A small fraction of it is used, and it's used by these things called sirtuins that consume NAD as an actual substrate in the process of DNA repair.”
Undated
Attia says the one positive resveratrol result came from mice force-fed an extremely high-fat diet, whose fatty livers crowded the chest.
“the investigators took a bizarre mouse model where they force-fed it, uh, an enormously high-fat diet.”
Undated
Peter Attia says skin sees about a 60 percent reduction in NAD over a lifetime, the largest decline of any tissue.
“skin over the course of your lifetime, will see about a 60% reduction in NAD”
Undated
In a human fatty-liver trial of NR plus a sirtuin activator, Attia says the primary outcome was null and only a subgroup analysis showed liver fat falling from about 20 to 15 percent at the low dose.
“The placebo group averaged 20% at the beginning, 20% at the end, but the single dose of the drug went from 20% to 15%, which was statistically significant.”
Undated
Attia says generic rapamycin costs about $5 a milligram, so his 8 mg weekly dose costs roughly $40 a week.
“it's about 5 bucks a milligram. That's pretty expensive. So if you're taking 8 milligrams a week, that's 40 bucks a week is probably what I spend on rapamycin.”
Undated
Peter Attia says the U.S. Nuclear Regulatory Commission recommends staying under 50 millisieverts of radiation a year.
“the NRC recommends that a human being, or at least an American, should expose themselves to less than 50 millisieverts of radiation a year.”
Undated
Attia says ambient background radiation at sea level amounts to about 1 millisievert per year.
“just ambient radiation living at sea level is 1 millisievert a year”
Episodes
- 29 Jul 2024Supplements for Longevity & Their Efficacy | Dr. Peter Attia2h 30m
- 20 Mar 2023Improve Vitality, Emotional & Physical Health & Lifespan | Dr. Peter Attia3h 23m
- 27 Dec 2021The Biology of Slowing & Reversing Aging | Dr. David Sinclair2h 5m
- 24 Jul 2023The LIFE-EXTENSION Doctor: "The ONE thing that's increasing your chance of early-death by 170.8%!" Peter Attia (E267)2h 0m