Topic
Resveratrol
6 facts from 2 episodes, in date order. These are what speakers said on the shows, each linked to the moment it was said. They aren't independently verified.
Undated
Sinclair says supplemental data from his resveratrol mouse study showed mice given resveratrol every other day on a normal diet lived dramatically longer than other groups.
“The mice that were given resveratrol every second day on a normal diet live dramatically longer than any other group.”
Andrew Huberman · The Biology of Slowing & Reversing Aging | Dr. David Sinclair, 0:39:33
Undated
Sinclair says he takes 1,000 milligrams of resveratrol daily, an amount he says cannot be obtained from red wine, and he said he would need about 200 glasses a day.
“So realistically, you can only get the one thousand milligrams that I take a day from a supplement that's pure.”
Andrew Huberman · The Biology of Slowing & Reversing Aging | Dr. David Sinclair, 0:46:58
Undated
Sinclair says that taking resveratrol with food raised his blood levels fivefold.
“And when we included it with food, the levels in my blood went up fivefold.”
Andrew Huberman · The Biology of Slowing & Reversing Aging | Dr. David Sinclair, 0:47:50
Undated
Sinclair says that altering resveratrol so it was no longer an antioxidant still extended yeast lifespan, suggesting antioxidant activity was not the mechanism.
“If we changed one atom to make it not an antioxidant, guess what? It still worked fine.”
David Sinclair · The Biology of Slowing & Reversing Aging | Dr. David Sinclair, 1:28:32
Undated
Attia says the Interventions Testing Program, run by Rich Miller, tested resveratrol and found it had no effect on lifespan.
“Rich Miller, who runs the ITP, the interventions testing program, which later tested resveratrol and found that it did, uh, categorically nothing.”
Peter Attia · Supplements for Longevity & Their Efficacy | Dr. Peter Attia, 0:50:22
Undated
Attia says the one positive resveratrol result came from mice force-fed an extremely high-fat diet, whose fatty livers crowded the chest.
“the investigators took a bizarre mouse model where they force-fed it, uh, an enormously high-fat diet.”
Peter Attia · Supplements for Longevity & Their Efficacy | Dr. Peter Attia, 0:50:22